Internal stresses and breakup of rigid isostatic aggregates in homogeneous and isotropic turbulence

By characterising the hydrodynamic stresses generated by statistically homogeneous and isotropic turbulence in rigid aggregates, we estimate theoretically the rate of turbulent breakup of colloidal aggregates and the size distribution of the formed fragments. The adopted method combines Direct Numerical Simulation of the turbulent field with a Discrete Element Method based on Stokesian dynamics. In this way, not only the mechanics of the aggregate is modelled in detail, but the internal stresses are evaluated while the aggregate is moving in the turbulent flow. We examine doublets and cluster-cluster isostatic aggregates, where the failure of a single contact leads to the rupture of the aggregate and breakup occurs when the tensile force at a contact exceeds the cohesive strength of the bond. Due to the different role of the internal stresses, the functional relationship between breakup frequency and turbulence dissipation rate is very different in the two cases. In the limit of very small and very large values, the frequency of breakup scales exponentially with the turbulence dissipation rate for doublets, while it follows a power law for cluster-cluster aggregates. For the case of large isostatic aggregates it is confirmed that the proper scaling length for maximum stress and breakup is the radius of gyration. The cumulative fragment distribution function is nearly independent of the mean turbulence dissipation rate and can be approximated by the sum of a small erosive component and a term that is quadratic with respect to fragment size.Comment: 31 pages, 19 figure

Black Cloud Randomization Test

The Black Cloud Randomization Test looks at a nontraditional question and attempts to answer the question using unique statistics. The purpose of this paper is to apply what has been learned throughout the years and apply this knowledge to a final project. Data for this project follows an emergency room’s on call schedule, as well as the number of traumas that came in during each day shift. The project builds on what has been already learned and helps to open a different way of working with statistics. The project was coded in the R software. With different restrictions, there are attempts to balance the strict definition of a permutation test with the practicality of the dataset involved. Looking at a rather large dataset for a traditional permutation test, the randomization test still nears the strength of the original test. Discussion is open to the accuracy and validity of the modified test

Effect of Poisson ratio on cellular structure formation

Mechanically active cells in soft media act as force dipoles. The resulting elastic interactions are long-ranged and favor the formation of strings. We show analytically that due to screening, the effective interaction between strings decays exponentially, with a decay length determined only by geometry. Both for disordered and ordered arrangements of cells, we predict novel phase transitions from paraelastic to ferroelastic and anti-ferroelastic phases as a function of Poisson ratio.Comment: 4 pages, Revtex, 4 Postscript figures include

Dbl oncogene expression in MCF-10 A epithelial cells disrupts mammary acinar architecture, induces EMT and angiogenic factor secretion.

The proteins of the Dbl family are guanine nucleotide exchange factors (GEFs) of Rho GTPases and are known to be involved in cell growth regulation. Alterations of the normal function of these proteins lead to pathological processes such as developmental disorders, neoplastic transformation, and tumor metastasis. We have previously demonstrated that expression of Dbl oncogene in lens epithelial cells modulates genes encoding proteins involved in epithelial-mesenchymal-transition (EMT) and induces angiogenesis in the lens. Our present study was undertaken to investigate the role of Dbl oncogene in epithelial cells transformation, providing new insights into carcinoma progression. To assess how Dbl oncogene can modulate EMT, cell migration, morphogenesis, and expression of pro-apoptotic and angiogenic factors we utilized bi- and three-dimensional cultures of MCF-10░A cells. We show that upon Dbl expression MCF-10░A cells undergo EMT. In addition, we found that Dbl overexpression sustain

reply to the letter to the editor by C.Nicolazzo et al.: "circulating cell-free DNA and circulating tumor cells as prognostic and predictive biomarkers in advanced non-small cell lung cancer patients treated with first-line chemotherapy"

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Pengaruh Kepemimpinan Partisipatif Terhadap Perilaku Kerja Pegawai Pada Dinas Penanaman Modal ESDM Dan Transmigrasi Provinsi Gorontalo

Penelitian ini bertujuan untuk mengetahui Pengaruh Kepemimpinan Partisipatif Terhadap Perilaku Kerja Pegawai. Metode penelitian yang digunakan dalam penelitian ini adalah metode kuantitatif dengan pendekatan kuantitatif deskriptif. Data yang digunakan adalah data primer yang diperoleh dari penyebaran kuesioner kepada pegawai di Dinas Penanaman Modal ESDM dan Transmigrasi Provinsi Gorontalo. Penarikan sampel dalam penelitian ini menggunakan rumus Slovin sehingga jumlah responden berjumlah 57. Analisis data dalam penelitian ini menggunakan analisis regresi linier sederhana dengan bantuan program SPSS 21. Hasil penelitian menunjukkan kepemimpinan partisipatif berpengaruh positif terhadap perilaku kerja pegawai. Koefisien determinasi dalam penelitian ini sebesar 55,4% yang berarti variabilitas perilaku kerja pegawai dapat dijelaskan oleh kepemimpinan partisipatif sebesar 55,4%. Sementara 44,6% dipengaruhi oleh variabel lain seperti kepemimpinan transformasional, lingkungan kerja, budaya organisasi, dan lain-lain. Dengan demikian, maka hipotesis teruji kebenarannya dan dapat diterima

Can International Patent Law Help Mitigate Cancer Inequity in LMICs?

Although low- and middle-income countries (LMICs) bear 75% of the cancer burden globally, their available resources to treat cancer constitute less than 5% of global health resources. This inequity makes it imperative to take appropriate measures to treat and prevent cancer in LMICs, which should include consideration of trade and patent policies. This article highlights some impediments to effective use of existing policies to promote access to treatment and prevention measures in LMICs and offers recommendations about next steps

Awake one stage bilateral thoracoscopic sympathectomy for palmar hyperhidrosis: a safe outpatient procedure

OBJECTIVE: To verify the feasibility and compare the results of thoracoscopic sympathectomy under local anaesthesia (LA) and spontaneous breathing vs. general anaesthesia (GA) with one-lung ventilation. METHODS: Two groups of consecutive patients underwent one stage bilateral T2-T3 thoracoscopic sympathectomy under LA (n=15) and GA (n=30) by the same surgical team for treatment of primary palmar hyperhidrosis. The groups were homogeneous for relevant demographic, physiological and clinical data, including pulmonary function. In both groups, patient's satisfaction was evaluated 24h after surgery by a simple interview and scored into five grades (1=very poor to 5=excellent), while quality of life (QOL) was evaluated by SF-36 and Nottingham's Health Profile questionnaires before and 6 months after surgery. A cost comparison between groups concerning devices, drugs, global in operating room time, medical personnel and hospital stay was also carried out. RESULTS: No operative mortality was recorded. The overall in operating room time for the whole bilateral procedure under LA was 63.55+/-10.58 vs. 86.05+/-5.75 under GA (P<0.01) and temperature increased in all patients from a baseline of 25.42+/-0.56 up to 32.15+/-0.84 degrees C. All patients undergone LA were discharged the same day after a chest roentgenogram and a short stay in the outpatient clinic. Among them three patients (20%) experienced a minimal (<30%) pneumothorax that required no treatment, while five (33.3%) had a trunk compensatory sweating that spontaneously resolved on the long run. Patients undergoing GA were discharged after a mean stay of 1.38+/-0.6 days. Among these, eight (26.6%) had prolonged trunk compensatory sweating that did not persist longer than 3 months. At a follow-up of 7.16+/-2.97 months, QOL was significantly improved with no difference between groups. The overall rate of satisfaction was greater in the LA group (P<0.05). CONCLUSIONS: In our study, awake one stage bilateral thoracoscopic sympathectomy for palmar hyperhidrosis could be safely and effectively performed as an outpatient procedure in patients refusing GA. Postoperative quality of life was equal to that in patients undergone the same procedure under GA, while patient satisfaction was better and cost were significantly reduced

The energy distribution of the first supernovae

The nature of the first Pop III stars is still a mystery and the energy distribution of the first supernovae is completely unexplored. For the first time we account simultaneously for the unknown initial mass function (IMF), stellar mixing, and energy distribution function (EDF) of Pop III stars in the context of a cosmological model for the formation of a MW-analogue. Our data-calibrated semi-analytic model is based on a N-body simulation and follows the formation and evolution of both Pop III and Pop II/I stars in their proper timescales. We discover degeneracies between the adopted Pop III unknowns, in the predicted metallicity and carbonicity distribution functions and the fraction of C-enhanced stars. Nonetheless, we are able to provide the first available constraints on the EDF, $dN/dE_\star \propto E_{\star}^{-\alpha_e}$ with $1\leq \alpha_e \leq2.5$. In addition, the characteristic mass of the Pop III IMF should be $m_{\rm ch}<100\:{\rm M_\odot}$, assuming a mass range consistent with hydrodynamical simulations (0.1-1000$\:{\rm M_\odot}$). Independent of the assumed Pop III properties, we find that all [C/Fe]>+0.7 stars (with [Fe/H]20\%$level, and all [C/Fe]>+2 stars at a$>95\%$level. All very metal-poor stars with$\rm [C/Fe]<0$ are predicted to be predominantly enriched by Pop III hypernovae and/or pair instabillity supernovae. To better constrain the primordial EDF, it is absolutely crucial to have a complete and accurate determination of the metallicity distribution function, and the properties of C-enhanced metal-poor stars (frequency and [C/Fe]) in the Galactic halo.Comment: 22 pages, 13 figure